Assessing the effect of childbearing on blood DNA methylation through comparison of parous and nulliparous females

Table 3 CpG sites significantly associated with childbearing history in discovery and replication analyses and with the same coefficient direction

CpGs		Discovery Cohort: IOW				Replication Cohort: ELEMENT		Associated Genes
CpGs	Coef. ^a Parous	SE	Raw p -value	FDR p -value	Coef. ^a Parous	SE	Raw p -value	Chr	Gene Name	UCSC RefGene Group
cg08288130	-0.2552	0.0645	0.0002	0.0009	-0.1625	0.0665	0.0188	8	DOK2	TSS1500
cg13375690	0.2371	0.0609	0.0002	0.0009	0.1422	0.0617	0.0260	8	PDE7A	Body
cg17672798	-0.1740	0.0447	0.0002	0.0009	-0.1445	0.0711	0.0482	10	ADARB2	Body
cg20955022	-0.1778	0.0468	0.0003	0.0010	-0.1732	0.0649	0.0107	7	SEMA3A	TSS1500
cg24737639	0.3731	0.0999	0.0004	0.0010	1.3769	0.5684	0.0197	12	NUP37; PARPBP	TSS1500;TSS200
cg02052068	-0.2273	0.0621	0.0004	0.0011	-0.2269	0.1045	0.0355	5	UGT3A1	TSS1500
cg08285768	0.2687	0.0790	0.0010	0.0017	0.1675	0.0820	0.0474	15	AKAP13	Body
cg16710348	0.3078	0.0950	0.0017	0.0024	0.1801	0.0699	0.0135	3	SLC15A2; SLC15A3	3’UTR
cg18379829	0.1104	0.0412	0.0091	0.0108	0.1542	0.0500	0.0036	1	PLD5; MAP1 LC3C
cg19086905	-0.1789	0.0682	0.0105	0.0123	-0.1631	0.0709	0.0262	15	ADAMTS17
cg06772580	0.0880	0.0350	0.0139	0.0161	0.1304	0.0405	0.0024	17	TP53I14	Body
cg01832012	-0.1388	0.0559	0.0151	0.0173	-0.0989	0.0473	0.0423	7	TPK1	Body
cg01537571	-0.3006	0.1273	0.0207	0.0231	-0.3071	0.1095	0.0075	15	TM2D3	TSS1500

^aNulliparous is reference; negative values indicate a decrease in DNAm in parous women

ISSN: 2730-7034