Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults

Table 3 Cross-tissue comparisons between blood-based biomarkers of biological aging (outcome variable) and (log) saliva-based telomere length (with lowest tertile as reference)

Biomarkers^a	β	95% CI	p-value
Physiological measure, phenotypic age	–
2nd tertile	− 2.30	− 4.30, − 0.30	0.024
3rd tertile	− 2.38	− 4.37, − 0.38	0.019
Horvath
2nd tertile	− 1.10	− 3.27, 1.07	0.320
3rd tertile	− 1.55	− 3.74, 0.63	0.163
Hannum
2nd tertile	− 1.61	− 3.59, 0.36	0.109
3rd tertile	− 2.40	− 4.39, − 0.40	0.018
Levine
2nd tertile	− 1.10	− 3.35, 1.14	0.335
3rd tertile	− 2.45	− 4.71, − 0.19	0.033
Skin & blood
2nd tertile	− 0.99	− 2.88, 0.88	0.298
3rd tertile	− 1.91	− 3.81, − 0.02	0.047
Lin
2nd tertile	0.12	− 2.40, 2.65	0.921
3rd tertile	− 3.45	− 6.00, − 0.91	0.008
Weidner
2nd tertile	− 1.27	− 4.05, 1.50	0.369
3rd tertile	− 3.97	− 6.76, − 1.17	0.005
VidalBralo
2nd tertile	− 1.49	− 2.93, − 0.06	0.040
3rd tertile	− 2.11	− 3.55, − 0.67	0.004
GrimAge
2nd tertile	− 1.75	− 3.56, 0.05	0.057
3rd tertile	− 3.33	− 5.15, − 1.51	< 0.001

^aMeasures per tertile increase in telomere length with lowest tertile as reference; models were adjusted for sex, sex and telomere length interaction, and time difference between saliva and blood draw

ISSN: 2730-7034