Fig. 6

EPICv2 facilitates somatic mutation analysis in cancer. A Distribution of nv probes among different Infinium design types. B Pie chart displaying genes targeted by nv probes. C Location of TP53 mutations targeted by nv probes. D EPICv2 reading of probes targeting KRAS G13 mutations in HCT116 cells. The following probes query the displayed mutations: nv-GRCh38-chr12-25,245,347–25,245,347-C-A_BC11 (G13V), GRCh38-chr12-25,245,347–25,245,347-C-T_BC11 (G13D), GRCh38-chr12-25,245,348–25,245,348-C-T_BC11 (G13S), GRCh38-chr12-25,245,347–25,245,347-C-G_TC11 (G13A); E Effect of the number of CpGs within 10 bp of the 3’-end on total intensities of nv probes. F Detection failure rate comparison between nv probes and other probe types. G Copy number profile of K562 cells, showing chromosome 9 deletion and chromosome 22 amplification. H Copy number profile of LNCaP cells, showing chromosome 2 and 13 deletions