Fig. 5

Annotation of EPICv2 probes for epigenetic clocks and cell type deconvolution panels. A Odds ratios of EPICv2-vs-EPICv1 across different ChromHMM features (ENCODE v2, Methods). Probe coverage comparison between EPICv2 and previous human methylation BeadChips for various applications including methylation clocks (B), epigenome-wide association studies (EWAS) (C), and cell-type deconvolution panels (D). Dashed line represent expected overlap from random probe selection for deletion. E Number of distinct pairwise contrasts covered by EPICv2 probes based on WGBS-derived human cell type panels. F Percentage of contrasts covered by varying numbers of probes, showcasing the EPICv2’s ability to capture signature of diverse cell types