A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy

Table 1 Demographic and clinical characteristics of participants in the discovery phase

Characteristics	Preeclampsia cases	Normotensive controls	p
Matched variables	n=28	n=28	p
Self-identified race, n (%)
Black	21 (75.0%)	21 (75.0%)	NA^*
White	7 (25.0%)	7 (25.0%)
Pre-pregnancy BMI, mean kg/m² (SD)	33.0 (7.5)	33.7 (7.5)
Lifetime smoking status (no), n (%)	18 (64.3%)	19 (67.9%)
Gestational age at sample collection, mean weeks (SD)
Trimester 1	8.7 (1.7)	8.8 (1.6)
Trimester 2	19.8 (1.7)	19.6 (0.8)
Trimester 3	37.0 (2.5)	37.4 (2.5)
	Preeclampsia cases	Normotensive controls	p^**
Unmatched variables	n=28	n=28	p^**
Parity, n (%)
Nulliparous (Yes)	21 (75.0%)	24 (85.7%)	0.38
(No)	7 (25.0%)	4 (14.3%)
Maternal age at birth, mean years (SD)	23.9 (5.0)	23.7 (4.2)	0.83
Gestational age at delivery, mean weeks (SD)	37.4 (2.5)	39.5 (1.3)	3.36×10^-4
Blood pressure < 20 weeks, mean mmHg (SD)
Systolic	112.8 (7.3)	111.5 (8.9)	0.63
Diastolic	70.1 (6.0)	66.8 (6.1)	0.08
Blood pressure prior to delivery, mean mmHg (SD)
Systolic	148.3 (6.9)	124.5 (6.1)	2.67×10^-14
Diastolic	90.5 (8.1)	71.1 (6.2)	2.21×10^-11

SD standard deviation
^*Variables matched based on self-identified race, pre-pregnancy BMI, self-reported smoking status, and gestational age at sample collection (± 2 weeks when possible) so p values are not reported
^**P values from paired t test comparing groups for continuous variables and exact McNemar’s test for dichotomous variable

ISSN: 2730-7034