Potential DNA methylation biomarkers for the detection of clear cell renal cell carcinoma identified by a whole blood-based epigenome-wide association study

Table 3 Comparison of ccRCC detection performance of DNAm levels using AUC-ROC

	Position	AUC-ROC	95% CI	Cutoff (%)	Sens	Spec
Discovery phase	134927030	0.877	0.812–0.942	36.6	0.84	0.76
	134927034	0.880	0.817–0.944	36.1	0.88	0.72
	134927079	0.907	0.850–0.964	41.7	0.82	0.84
	134927085	0.909	0.851–0.967	49.5	0.86	0.88
	134927103	0.908	0.852–0.964	54.6	0.84	0.84
	134927106	0.894	0.836–0.953	53.3	0.86	0.78
	Sum of six CpGs	0.922	0.871–0.973	283.4	0.82	0.92
Replication phase	134927030	0.834	0.753–0.915	43.8	0.70	0.90
	134927034	0.849	0.771–0.926	42.2	0.70	0.88
	134927079	0.850	0.776–0.925	45.9	0.60	0.98
	134927085	0.847	0.768–0.925	47.7	0.72	0.90
	134927103	0.855	0.775–0.934	51.5	0.72	0.96
	134927106	0.856	0.778–0.934	48.5	0.77	0.83
	Sum of six CpGs	0.871	0.800–0.941	285.9	0.68	0.94

AUC-ROC area under the receiver operating characteristic curve, 95% CI 95% confidence interval, Sens sensitivity, Spec specificity, ccRCC clear cell renal cell carcinoma, DNAm DNA methylation

ISSN: 2730-7034