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Table 3 Participant characteristics by trajectory groups for cg25713625 (STEAP3) discovery and replication samples

From: Iron homeostasis pathway DNA methylation trajectories reveal a role for STEAP3 metalloreductase in patient outcomes after aneurysmal subarachnoid hemorrhage

 

Discovery (n = 260)

Replication (n = 100)

Variable

Group 1 (low)

Group 2 (intermediate)

Group 3 (high)

p

Group 1 (low)

Group 2 (intermediate)

Group 3 (high)

p

Group membership, n (%)

29 (11.1)

166 (63.8)

65 (25.0)

 

6 (6.0)

68 (68.0)

26 (26.0)

 

Age, mean (SD)

52.3 (12.2)

53.0 (10.8)

53.6 (11.2)

0.862a

65.2 (6.6)

54.4 (12.0)

51.0 (11.6)

0.03a

Sex, female, n (%)

13 (44.8)

118 (71.1)

48 (73.8)

0.011b

4 (66.7)

53 (77.9)

19 (73.1)

0.667c

Self-identified race, white, n (%)

20 (69.0)

147 (88.6)

58 (89.2)

0.013b

6 (100)

61 (89.7)

24 (92.3)

1c

Fisher grade

        

 2

6 (20.7)

54 (32.5)

18 (27.7)

0.558b

5 (83.3)

27 (39.7)

9 (34.6)

0.719b,d

 3

14 (48.3)

80 (48.2)

32 (49.2)

1 (16.7)

30 (44.1)

12 (46.2)

 4

9 (31.0)

32 (19.3)

15 (23.1)

0

11 (16.2)

5 (19.2)

Intervention, coil, n (%)

16 (55.2)

99 (59.6)

40 (61.5)

0.845b

4 (66.7)

46 (67.6)

16 (61.5)

0.875c

  1. Discovery, trajectory groups depicted in Fig. 2a; Replication, trajectory groups depicted in Fig. 2c; SD, standard deviation; significant associations based on p < 0.05 have been bolded. aOne-way analysis of variance; bchi-square test of independence; cFisher’s exact test; dcomputed by combining low and intermediate groups because of 0 cell count
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Epigenetics Communications

ISSN: 2730-7034