Fig. 4

Regression coefficients in simulated discovery (x-axis) and replication (y-axis) samples. Results from 10,000 simulation experiments are plotted. Black and red dots mark the 1229 samplings which yielded a discovery p-value < 0.05; the background gray dots represent the remaining non-significant ones (p-value > 0.05). Coefficients were derived from a model where M value at cg18031596 was regressed on DCI and covariates. Marginal distributions are indicated by the rug plots along the inner side of the axes. The horizontal and vertical dashed line identify the observed replication coefficient (−0.2) and observed discovery coefficient (0.1; can be found in Table S3), respectively. Red dots represent a flip of association direction with the simulated replication coefficient more extreme than the observed replication coefficient