Table 4 Demographic and clinical characteristics of participants in the trimester 3 replication phase
From: A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy
Characteristics | Validation sample | Independent sample | Combined sample | ||||||
|---|---|---|---|---|---|---|---|---|---|
Matched variables | Preeclampsia cases (n= 25) | Normotensive controls (n= 28) | p | Preeclampsia cases (n= 64) | Normotensive controls (n= 50) | p | Preeclampsia cases (n= 89) | Normotensive controls (n= 78) | p |
Race, n (%) | |||||||||
 Black | 18 (72.0%) | 21 (75.0%) | NA* | 7 (10.9%) | 5 (10.0%) | NA* | 25 (28.1%) | 26 (33.3%) | NA* |
 White | 7 (28.0%) | 7 (25.0%) | 57 (89.1%) | 45 (90.0%) | 64 (71.9%) | 52 (66.7%) | |||
Pre-pregnancy BMI, mean kg/m2 (SD) | 32.5 (7.0) | 33.7 (7.5) | 25.5 (5.0) | 24.7 (4.7) | 27.5 (6.4) | 28.0 (7.2) | |||
Gestational age at sample collection, mean weeks (SD) | Â | Â | Â | Â | Â | Â | |||
 Trimester 3 | 37.0 (2.5) | 37.4 (2.5) | 36.7 (3.3) | 38.1 (2.2) | 36.8 (3.1) | 37.9 (2.3) | |||
Unmatched variables | Preeclampsia cases (n= 25) | Normotensive controls (n= 28) | p** | Preeclampsia cases (n= 64) | Normotensive controls (n= 50) | p** | Preeclampsia cases (n= 89) | Normotensive controls (n= 78) | p** |
Parity, n (%) | |||||||||
 Nulliparous (Yes) | 18 (72.0%) | 24 (85.7%) | 0.10 | 52 (81.3%) | 38 (76.0%) | 0.48 | 70 (78.7%) | 62 (79.5%) | 0.89 |
  (No) | 7 (28.0%) | 4 (14.3%) |  | 12 (18.7%) | 12 (24.0%) |  | 19 (21.3%) | 16 (20.5%) |  |
Maternal age at birth, mean years (SD) | 24.2 (5.2) | 23.7 (4.2) | 0.70 | 27.2 (6.7) | 28.0 (5.8) | 0.53 | 26.4 (6.5) | 26.4 (5.7) | 0.96 |
Gestational age at delivery, mean weeks (SD) | 37.3 (2.5) | 39.5 (1.3) | 6.16×10-4 | 36.8 (3.3) | 38.8 (1.2) | 8.46×10-7 | 36.9 (3.1) | 39.1 (1.3) | 5.09×10-9 |
Blood pressure <20 weeks, mean mmHg (SD) | |||||||||
 Systolic | 113.0 (7.7) | 111.5 (8.9) | 0.40 | 114.2 (9.4) | 114.7 (8.4) | 0.78 | 113.9 (8.9) | 113.5 (8.7) | 0.80 |
 Missing | 0 | 0 | / | 3 | 1 | / | 3 | 1 | / |
 Diastolic | 70.0 (5.9) | 66.8 (6.1) | 0.05 | 70.2 (7.4) | 69.7 (5.3) | 0.71 | 70.1 (7.0) | 68.7 (5.7) | 0.15 |
 Missing | 0 | 0 | / | 3 | 1 | / | 3 | 1 | / |
Blood pressure prior to delivery, mean mmHg (SD) | |||||||||
 Systolic | 148.8 (7.1) | 124.5 (6.1) | 1.02×10-12 | 155.5 (15.1) | 120.8 (11.9) | 2.43×10-19 | 153.6 (13.7) | 122.1 (10.3) | 9.82×10-28 |
 Diastolic | 91.2 (8.3) | 71.1 (6.2) | 3.54×10-9 | 92.6 (8.8) | 73.8 (7.3) | 5.83×10-18 | 92.2 (8.6) | 72.8 (7.0) | 3.30×10-26 |