Fig. 5

HOXA3 and MAP4K1 in inflammatory disease. a Flow chart of online data selection methodology. b Methylation expressed as a β-value for leukocytes (first panel, red), cortical neurons (second panel, blue), and the difference in β-value between the two (third panel, black) for the HOXA cluster. Data from the Moss et al. [10] dataset GEO accession: (GSE122126). The bottom panel is a reconstructed mini-Manhattan plot of the HOXA cluster methylation with respect to Braak stage classification in Alzheimer disease. P-values were generated using a linear regression model of DNA methylation with respect to each Braak stage classification (0–6). Red circles indicate an increase in methylation (β-value) by ≥ 0.1 as Braak stage increases, green a decrease ≥ 0.1, and black a change < 0.1. Data from Smith et al. [30] (GEO accession: GSE80970)