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Table 4 Association between epigenetic age acceleration and metabolic syndrome components in the CoDuBu study, south-central Côte d’Ivoire

From: Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire

Predictor Model High blood pressure Impaired fasting glucose Low high-density lipoprotein High triglyceride Central obesity Metabolic syndrome Metabolic syndrome severity
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
IEAA 1 1.17 (0.93, 1.46) 1.01 (0.82, 1.23) 0.89 (0.73, 1.08) 0.88 (0.61, 1.27) 0.86 (0.68, 1.09) 0.77 (0.60, 0.99)** 0.94 (0.79, 1.13)
2 1.16 (0.92, 1.46) 1.01 (0.82, 1.25) 1.00 (0.80, 1.23) 0.85 (0.58, 1.26) 0.97 (0.74, 1.28) 0.83 (0.63, 1.10) 1.02 (0.86, 1.22)
3 1.18 (0.92, 1.50) 1.01 (0.82, 1.25) 0.99 (0.80, 1.23) 0.83 (0.53, 1.29) 0.90 (0.60, 1.36) 0.78 (0.57, 1.08) 1.03 (0.86, 1.24)
EEAA 1 1.14 (0.91, 1.43) 1.30 (1.06, 1.60)** 0.98 (0.80, 1.20) 1.26 (0.88, 1.80) 0.77 (0.61, 0.98)** 1.04 (0.82, 1.33) 1.09 (0.91, 1.30)
2 1.28 (1.01, 1.63)** 1.19 (0.95, 1.48) 1.07 (0.86, 1.33) 1.23 (0.85, 1.79) 0.98 (0.74, 1.31) 1.20 (0.91, 1.59) 1.21 (1.01, 1.46)**
3 1.28 (1.00, 1.64)* 1.19 (0.96, 1.48) 1.07 (0.86, 1.32) 1.29 (0.86, 1.95) 0.81 (0.53, 1.22) 1.23 (0.90, 1.57) 1.23 (1.02, 1.49)**
PhenoAA 1 1.17 (0.93, 1.46) 1.25 (1.03, 1.53)** 1.09 (0.89, 1.33) 1.28 (0.90, 1.84) 0.98 (0.78, 1.24) 1.18 (0.92, 1.50) 1.22 (1.02, 1.47)**
2 1.24 (0.98, 1.58)* 1.19 (0.96, 1.47) 1.12 (0.90, 1.38) 1.33 (0.91, 1.94) 1.09 (0.82, 1.45) 1.25 (0.95, 1.64) 1.26 (1.04, 1.54)**
3 1.22 (0.96, 1.56) 1.19 (0.96, 1.47) 1.10 (0.90, 1.37) 1.30 (0.86, 1.94) 0.97 (0.64, 1.46) 1.21 (0.89, 1.64) 1.26 (1.03, 1.55)**
4 1.20 (0.93, 1.54) 1.06 (0.84, 1.33) 1.14 (0.90, 1.44) 1.61 (1.02, 2.64)** 1.12 (0.83, 1.52) 1.18 (0.88, 1.59) 1.20 (0.97, 1.47)*
GrimAA 1 0.95 (0.75, 1.18) 1.10 (0.90, 1.34) 0.87 (0.71, 1.07) 1.00 (0.70, 1.44) 0.65 (0.51, 0.84)** 0.80 (0.62, 1.02)* 0.85 (0.71, 1.02)*
2 0.98 (0.75, 1.27) 1.07 (0.85, 1.36) 1.18 (0.93, 1.49) 1.09 (0.76, 1.66) 0.93 (0.67, 1.27) 1.06 (0.79, 1.42) 1.08 (0.86, 1.37)
3 0.98 (0.75, 1.29) 1.07 (0.85, 1.36) 1.19 (0.94, 1.51) 1.05 (0.66, 1.68) 0.81 (0.51, 1.29) 1.05 (0.79, 1.49) 1.16 (0.91, 1.47)
4 0.98 (0.73, 1.29) 0.99 (0.77, 1.29) 1.24 (0.95, 1.61) 1.11 (0.68, 1.82) 0.96 (0.67, 1.33) 1.03 (0.75, 1.43) 1.06 (0.83, 1.35)
  1. CI confidence interval, CoDuBu Côte d’Ivoire dual burden of disease study, EEAA extrinsic epigenetic age acceleration, GrimAA Grim age acceleration, IEAA intrinsic epigenetic age acceleration, OR odds ratio, PhenoAA Pheno age acceleration. Estimates represent odds of each phenotype in relation to one standard deviation increase in each epigenetic acceleration measure. All estimates were from multivariable binomial and ordinal logistic regression models. *p value < 0.1. **p < 0.05
  2. Model 1 adjusted for chronological age
  3. Model 2 Model 1 + sex, education, household wealth index, urbanization, smoking status, alcohol consumption and physical activity
  4. Model 3: Model 2 + body mass index
  5. Model 4 Model 3 + leukocyte composition