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Table 2 Performance of epigenetic clocks as biomarkers of chronological age in the CoDuBu study, south-central Côte d’Ivoire

From: Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire

  All participants, n = 393 Apparently healthy participants, n = 44
Chronological age HorvathAge HannumAge PhenoAge GrimAge Chronological age HorvathAge HannumAge PhenoAge GrimAge
Mean (SD), age (years) 41.5 (13.1) 47.3 (11.3) 39.6 (12.0) 33.7 (13.8) 49.6 (10.9) 36.6 (14.5) 42.7 (11.8) 34.8 (13.0) 27.2 (15.9) 45.9 (13.4)
Mean (SD), EAD (years) 5.8 (7.2) − 1.9 (6.6) − 7.8 (7.4) 8.1 (4.8) 6.1 (7.3) − 1.8 (5.6) − 9.4 (7.4) 9.3 (5.4)
95% limits of EAD agreement (years) − 8.4, 19.9 − 14.8, 11.1 − 22.3, 6.7 − 1.3, 17.6 − 8.3, 20.4 − 12.7, 9.1 − 23.8, 5.1 − 1.3, 19.9
Lin’s rC of EA with chronological age 0.74 0.85 0.73 0.75 0.76 0.91 0.74 0.75
95% CI of Lin’s rC a 0.70, 0.78 0.82, 0.88 0.68, 0.76 0.72, 0.78 0.60, 0.87 0.84, 0.95 0.61, 0.83 0.61, 0.85
Lin’s coefficient of bias 0.89 0.99 0.85 0.80 0.88 0.99 0.83 0.81
Mean (SD), EAA (years) 0 (6.3) 0 (6.0) 0 (7.3) 0 (3.9) − 1.0 (5.9) − 0.9 (5.0) − 2.0 (7.3) 0.1 (5.7)
Pearson’s r of EA with chronological age 0.83 0.86 0.85 0.93 0.86 0.92 0.89 0.93
Pearson’s r of EAD with chronological age − 0.50 − 0.41 − 0.18 − 0.59 − 0.59 − 0.44 − 0.05 − 0.39
Pearson’s r of EAA with chronological age 0.00 0.00 0.00 0.00 − 0.05 0.10 0.14 0.21
  1. CI confidence interval, EA epigenetic age, EAA epigenetic age acceleration, EAD epigenetic age difference, rC, Lin’s concordance correlation for strength of agreement between EA and chronological age. Chronological age was measured at health examination, and epigenetic age measures were estimated from blood sample taken at health examination. Apparently healthy participants defined as non-smoking participants with none of the metabolic syndrome features. Coefficient of bias derived as the ratio of Lin’s rC and Pearson’s r. EAD is the absolute difference between epigenetic and chronological age. EAA is the unexplained residual of regression of EA on chronological age
  2. aBias-corrected 95% confidence intervals using bootstrap technique with 10,000 replications