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Table 5 Replication results of binary logistic regression examining associations of cg25713625 (STEAP3) with patient outcomes while controlling for age, sex, self-identified race, and Fisher grade

From: Iron homeostasis pathway DNA methylation trajectories reveal a role for STEAP3 metalloreductase in patient outcomes after aneurysmal subarachnoid hemorrhage

Replication, polynomial order 002, Fig. 2c

Group 3 (high) vs. combined group 1 (low) and group 2 (intermediate)

Outcome

OR

95% CI

pc

GOS-3

8.190

2.51 to 31.85

0.0010a

GOS-12

6.257

1.85 to 24.53

0.0047a

Death-3

2.253

1.26 to 4.23

0.0080a

Death-12

2.028

1.10 to 3.92

0.0272b

  1. Corresponds to trajectory groups depicted in Fig. 2c; GOS-3, Glasgow Outcome Scale at 3 months (unfavorable = 1–3); GOS-12, Glasgow Outcome Scale at 12 months (unfavorable = 1–3); Death-3, death at 3 months; Death-12, death at 12 months. aSignificant associations (meeting empirical significance level) have been bolded. bSuggestive associations (unadjusted p < 0.05) have been underlined. cEmpirical significance threshold = 0.0241 (calculated based on the minimum of 4 p-values in permutation testing)