Epigenetics Communications

Table 4 Outcome distributions by trajectory group in cg25713625 (STEAP3) discovery and replication samples

From: Iron homeostasis pathway DNA methylation trajectories reveal a role for STEAP3 metalloreductase in patient outcomes after aneurysmal subarachnoid hemorrhage

GOS-3
	Discovery (n = 214)			Replication (n = 99)
Group	Favorable, n	Unfavorable, n	% Unfavorable	Favorable, n	Unfavorable, n	% Unfavorable
3 (high)	23	29	55.77	10	16	61.54
2 (intermediate)	101	38	27.34	45	22	32.84
1 (low)	19	4	17.39	6	0	0.00
GOS-12
	Discovery (n = 204)			Replication (n = 93)
Group	Favorable, n	Unfavorable, n	% Unfavorable	Favorable, n	Unfavorable, n	% Unfavorable
3 (high)	32	22	40.74	12	13	52.00
2 (intermediate)	97	29	23.02	46	16	25.81
1 (low)	22	2	8.33	6	0	0.00
Death-3
	Discovery (n = 232)			Replication (n = 99)
Group	No, n	Yes, n	% Yes	No, n	Yes, n	% Yes
3 (high)	40	17	29.82	15	11	42.31
2 (intermediate)	130	21	13.91	54	13	19.40
1 (low)	23	1	4.17	6	0	0.00
Death-12
	Discovery (n = 204)			Replication (n = 93)
Group	No, n	Yes, n	% Yes	No, n	Yes, n	% Yes
3 (high)	35	19	35.19	14	11	44.00
2 (intermediate)	103	23	18.25	47	15	24.19
1 (low)	22	2	8.33	6	0	0.00

Discovery, trajectory groups depicted in Fig. 2a; Replication, trajectory groups depicted in Fig. 2c; GOS-3, Glasgow Outcome Scale at 3 months (favorable = 4–5, unfavorable=1–3); GOS-12, Glasgow Outcome Scale at 12 months (favorable = 4–5, unfavorable = 1–3); Death-3, death at 3 months; Death-12, death at 12 months

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