Fig. 2

Discovery and replication DNA methylation trajectory plots for top hits. Inferred trajectory groups computed using group-based trajectory analysis separated by discovery phase (base models and CTH-adjusted models) and replication phase (base models only) with group membership percentages depicted; y-axis scale, 0 to 1; the CTH-adjusted trajectory model for cg08553327 (TNF) did not pass posterior model quality control and therefore is not included here; bars plot the 95% confidence interval for the estimate; DNA methylation data were analyzed as M values and converted to beta values for plot presented here; a table with exact DNA methylation levels as measured by beta values is presented in Table S6