Table 3 Bivariate associations between participant characteristics and DNA methylation age acceleration metrics independent of trajectory group

Age acceleration metric

Est (SE)

95% CI

p

Est (SE)

95% CI

p

 Horvath (CSF)

− 0.96 (0.41)

− 1.78 to − 0.15

0.02^a

0.31 (0.58)

− 0.84 to 1.45

0.60

 Horvath (CSF) + CTH

− 0.63 (0.50)

− 1.62 to 0.37

0.22

1.10 (0.67)

− 0.22 to 2.42

0.10

 Horvath (blood)

− 0.24 (0.93)

− 2.09 to 1.61

0.80

− 0.36 (1.23)

− 2.82 to 2.10

0.77

 Horvath (blood) + CTH

− 0.30 (0.73)

− 1.76 to 1.15

0.96

0.34 (0.97)

− 1.60 to 2.27

0.73

 Hannum (CSF)

− 2.78 (0.44)

− 3.65 to − 1.92

8.75E−10^a

− 0.92 (0.65)

− 2.20 to 0.36

0.16

 Hannum (CSF) + CTH

− 2.18 (0.55)

− 3.27 to − 1.10

0.0001^a

− 0.06 (0.77)

− 1.58 to 1.46

0.94

 Hannum (blood)

− 0.69 (0.80)

− 2.29 to 0.91

0.39

− 2.23 (1.04)

− 4.30 to − 0.15

0.04^a

 Hannum (Blood) + CTH

− 0.53 (0.58)

− 1.69 to 0.63

0.37

− 0.21 (0.78)

− 1.76 to 1.35

0.79

 Levine (CSF)

− 0.30 (0.61)

− 1.50 to 0.90

0.62

1.81 (0.84)

0.84 to 2.22

0.03^a

 Levine (CSF) + CTH

0.99 (0.75)

− 0.49 to 2.47

0.19

2.94 (0.97)

1.02 to 4.87

0.003^a

 Levine (blood)

− 0.11 (1.05)

− 2.2 to 1.99

0.92

− 1.16 (1.39)

− 3.93 to 1.62

0.41

 Levine (blood) + CTH

0.12 (0.95)

− 1.77 to 2.01

0.90

0.17 (1.26)

− 2.34 to 2.69

0.89

 Zhang (CSF)

− 0.31 (0.29)

− 0.88 to 0.26

0.29

− 0.58 (0.40)

− 1.37 to 0.21

0.15

 Zhang (CSF) + CTH

− 0.09 (0.44)

− 0.95 to 0.78

0.85

0.04 (0.58)

− 1.11 to 1.19

0.95

 Zhang (blood)

0.74 (0.60)

− 0.45 to 1.93

0.22

− 0.25 (0.80)

− 1.85 to 1.35

0.75

 Zhang (blood) + CTH

0.73 (0.53)

− 0.33 to 1.79

0.17

0.43 (0.72)

− 1.00 to 1.85

0.55

Age acceleration metric

Est (SE)

95% CI

p

Est (SE)

95% CI

p

 Horvath (CSF)

− 0.07 (0.41)

− 0.89 to 0.74

0.86

− 0.18 (0.14)

− 0.46 to 0.10

0.22

 Horvath (CSF) + CTH

0.24 (0.49)

− 0.74 to 1.21

0.63

0.04 (0.24)

− 0.42 to 0.51

0.86

 Horvath (blood)

− 0.86 (0.88)

− 2.62 to 0.90

0.33

0.10 (0.31)

− 0.51 to 0.71

0.74

 Horvath (blood) + CTH

− 0.83 (0.68)

− 2.19 to 0.54

0.23

0.24 (0.38)

− 0.52 to 0.99

0.53

 Hannum (CSF)

− 0.57 (0.47)

− 1.49 to 0.35

0.22

0.08 (0.13)

− 0.17 to 0.33

0.52

 Hannum (CSF) + CTH

0.17 (0.56)

− 0.94 to 1.27

0.77

0.19 (0.21)

− 0.21 to 0.60

0.35

 Hannum (blood)

− 1.11 (0.76)

− 2.62 to 0.40

0.15

0.14 (0.35)

− 0.55 to 0.83

0.69

 Hannum (blood) + CTH

− 0.23 (0.56)

− 1.34 to 0.89

0.69

0.02 (0.03)

− 0.05 to 0.08

0.61

 Levine (CSF)

0.84 (0.61)

− 0.36 to 2.04

0.17

0.01 (0.09)

− 0.18 to 0.20

0.89

 Levine (CSF) + CTH

2.09 (0.70)

0.70 to 3.48

0.003^a

− 0.09 (0.16)

− 0.40 to 0.22

0.56

 Levine (blood)

− 0.06 (0.97)

− 2.05 to 1.93

0.96

0.18 (0.26)

− 0.35 to 0.70

0.51

 Levine (blood) + CTH

0.44 (0.90)

− 1.34 to 2.23

0.62

0.03 (0.05)

− 0.07 to 0.13

0.55

 Zhang (CSF)

− 0.17 (0.29)

− 0.74 to 0.41

0.57

− 0.04 (0.20)

− 0.43 to 0.36

0.85

 Zhang (CSF) + CTH

0.46 (0.42)

− 0.38 to 1.29

0.28

− 0.01 (0.26)

− 0.53 to 0.52

0.98

 Zhang (blood)

− 0.33 (0.57)

− 1.47 to 0.82

0.57

− 0.42 (0.46)

− 1.33 to 0.50

0.37

 Zhang (blood) + CTH

− 0.31 (0.51)

− 1.33 to 0.72

0.56

− 0.03 (0.03)

− 0.09 to 0.03

0.32