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Table 2 Summary of Horvath, Hannum, and Zhang cerebrospinal fluid DNA methylation age acceleration trajectory group characteristics

From: Characterization of cerebrospinal fluid DNA methylation age during the acute recovery period following aneurysmal subarachnoid hemorrhage

 

Horvath (CSF)

Horvath (CSF) + CTH

Variable

Group 1

Group 2

Group 3

Group 4

p

Group 1

Group 2

Group 3

Group 4

p

Group membership, n (%)

8 (2.9)

115 (42.1)

112 (41.0)

38 (13.9)

 

23 (8.4)

135 (49.5)

95 (34.8)

20 (7.3)

 

Age, mean (SD)

48.5 (14.7)

53.2 (11.9)

53.0 (10.6)

52.5 (9.3)

0.863b

48.7 (11.6)

54.0 (11.8)

52.7 (10.0)

51.7 (9.5)

0.189b

DNAmAge, CSF, mean (SD)

46.5 (7.1)

55.1 (6.5)

58.5 (5.7)

62.0 (5.4)

4.265E-13b

50.7 (6.5)

56.3 (6.5)

58.9 (5.8)

62.2 (6.1)

1.647E-09b

Age Acceleration, CSF, mean (SD)

-8.3 (3.5)

-2.3 (1.3)

1.2 (1.1)

5.0 (1.7)

<2.2E-16b

-4.3 (1.9)

-1.4 (2.3)

1.9 (1.7)

5.7 (1.9)

<2.2E-16b

DNAmAge, Blood, mean (SD)

42.3 (9.2)

56.3 (8.6)

56.7 (7.0)

59.4 (5.1)

0.047b

48.6 (7.0)

56.6 (7.9)

58.9 (6.8)

59.7 (3.2)

6.509E-15b

Age Acceleration, Blood, mean (SD)

-1.1 (3.6)

-2.3 (3.8)

1.1 (2.3)

3.7 (1.7)

2.935E-06b

-4.5 (2.8)

-1.2 (2.2)

2.3 (2.7)

4.6 (2.3)

6.509E-15b

Sex, female, n (%)

6 (75.0)

87 (75.7)

71 (63.4)

23 (60.5)

0.15c

19 (82.6)

97 (71.9)

56 (58.9)

15 (75.0)

0.06c

Race, White, n (%)

6 (75.0)

105 (91.3)

95 (84.8)

32 (84.2)

0.30c

19 (82.6)

121 (89.6)

82 (86.3)

16 (80.0)

0.54c

Fisher

          

2

1 (12.5)

28 (24.3)

41 (36.6)

11 (28.9)

0.36c

5 (21.7)

40 (29.6)

31 (32.6)

5 (25.0)

0.88c

3

6 (75.0)

59 (51.3)

51 (45.5)

19 (50.0)

12 (52.2)

65 (48.1)

46 (48.4)

12 (60.0)

4

1 (12.5)

28 (24.3)

20 (17.9)

8 (21.1)

6 (26.1)

30 (22.2)

18 (18.9)

3 (15.0)

Smoking history, n (%)

          

No

2 (25.0)

38 (33.0)

35 (31.2)

13 (34.2)

0.95c

6 (26.1)

47 (34.8)

27 (28.4)

8 (40.0)

0.56c

Yesa

6 (75.0)

76 (66.1)

75 (67.0)

24 (63.2)

16 (69.6)

87 (64.5)

67 (70.5)

11 (55.0)

Unknown

0

1 (0.9)

2 (1.8)

1 (2.6)

 

1 (4.3)

1 (0.7)

1 (1.1)

1 (5.0)

 

BMI, mean (SD)

26.5 (5.2)

29.3 (8.8)

27.1 (5.8)

27.8 (5.3)

0.145b

27.4 (6.8)

28.8 (7.9)

27.1 (6.3)

28.4 (6.6)

0.371b

 

Hannum (CSF)

Hannum (CSF) + CTH

Variable

Group 1

Group 2

Group 3

Group 4

p

Group 1

Group 2

Group 3

Group 4

p

Group membership, n (%)

15 (5.5)

121 (44.3)

131 (48.0)

6 (2.2)

 

10 (3.7)

102 (37.4)

124 (45.4)

37 (13.6)

 

Age, mean (SD)

54.5 (9.9)

53.5 (11.2)

52.0 (11.3)

56.7 (7.3)

0.531b

53.5 (11.7)

53.6 (11.2)

51.6 (10.7)

55.0 (11.7)

0.333b

DNAmAge, CSF, mean (SD)

55.0 (5.9)

56.8 (6.4)

57.5 (7.1)

62.8 (3.8)

4.809E-09b

55.7 (5.7)

56.9 (6.9)

56.7 (6.4)

60.1 (7.2)

8.487E-07b

Age Acceleration, CSF, mean (SD)

-3.0 (3.5)

-0.7 (2.6)

0.8 (3.3)

3.6 (1.8)

<2.2E-16b

-1.8 (4.1)

-0.7 (2.8)

0.1 (3.2)

1.8 (3.0)

<2.2E-16b

DNAmAge, Blood, mean (SD)

54.4 (5.1)

57.5 (8.3)

55.7 (7.8)

53.0 (6.2)

0.789b

53.5 (6.6)

55.4 (8.7)

57.1 (6.9)

60.1 (7.8)

0.030b

Age Acceleration, Blood, mean (SD)

-0.7 (2.5)

-0.3 (4.0)

0.4 (3.3)

-0.4 (2.8)

0.003b

-0.6 (2.6)

-1.7 (3.4)

1.4 (2.9)

2.5 (3.9)

1.495E-06b

Sex, female, n (%)

14 (93.3)

100 (82.6)

72 (55.0)

1 (16.7)

1.1E-7c

9 (90.0)

88 (86.3)

75 (60.5)

15 (40.5)

1.1E-7c

Race, White, n (%)

11 (73.3)

104 (86.0)

118 (90.1)

5 (83.3)

0.28c

8 (80.0)

83 (81.4)

113 (91.1)

34 (91.9)

0.11c

Fisher

          

2

5 (33.3)

34 (28.1)

42 (32.1)

1 (16.7)

0.62c

2 (20.0)

27 (26.5)

40 (32.3)

12 (32.4)

0.95c

3

8 (53.3)

58 (47.9)

66 (50.4)

3 (50.0)

6 (60.0)

52 (51.0)

59 (47.6)

18 (48.6)

4

2 (13.3)

29 (24.0)

23 (17.6)

2 (33.3)

2 (20.0)

23 (22.5)

25 (20.2)

7 (18.9)

Smoking history, n (%)

          

No

3 (0.2)

39 (32.2)

44 (33.6)

2 (33.3)

0.75c

3 (0.3)

29 (28.4)

42 (33.9)

14 (37.8)

0.68c

Yesa

12 (0.8)

79 (65.3)

85 (64.9)

4 (66.7)

6 (0.6)

73 (71.6)

79 (63.7)

23 (62.2)

Unknown

0

3 (2.5)

2 (1.5)

0

 

1 (0.1)

0

3 (2.4)

0

 

BMI, mean (SD)

26.3 (8.7)

28.1 (7.6)

28.5 (6.8)

26.8 (1.8)

0.720b

25.4 (3.0)

28.3 (8.5)

28.1 (6.6)

28.6 (6.0)

0.698b

 

Zhang (CSF)

     

Variable

Group 1

Group 2

Group 3

Group 4

p

     

Group membership, n (%)

47 (17.2)

148 (54.2)

71 (26.0)

7 (2.6)

      

Age, mean (SD)

52.2 (14.1)

53.3 (10.8)

52.6 (9.6)

52.3 (10.5)

0.940b

     

DNAmAge, CSF, mean (SD)

50.3 (11.5)

53.9 (9.0)

56.2 (8.1)

59.3 (8.7)

0.004b

     

Age Acceleration, CSF, mean (SD)

-3.1 (0.9)

-0.4 (0.9)

2.4 (0.9)

5.8 (1.8)

<2.2E-16b

     

DNAmAge, Blood, mean (SD)

47.6 (12.4)

55.7 (10.2)

56.1 (7.5)

52.1 (4.0)

0.063b

     

Age Acceleration, Blood, mean (SD)

-2.8 (1.1)

-0.2 (1.7)

2.3 (1.3)

2.4 (4.7)

2.583E-12b

     

Sex, female, n (%)

37 (78.7)

98 (66.2)

49 (69.0)

3 (42.9)

0.19c

     

Race, White, n (%)

40 (85.1)

127 (85.8)

64 (90.1)

6 (85.7)

1.1E-7c

     

Fisher

          

2

11 (23.4)

45 (30.4)

24 (33.8)

1 (14.3)

0.76c

     

3

26 (55.3)

73 (49.3)

31 (43.7)

5 (71.4)

     

4

10 (21.3)

30 (20.3)

16 (22.5)

1 (14.3)

     

Smoking history, n (%)

          

No

14 (29.8)

49 (33.1)

23 (32.4)

2 (28.6)

0.97c

     

Yesa

32 (68.1)

96 (64.9)

48 (67.6)

5 (71.4)

     

Unknown

1 (2.1)

3 (2.0)

0

0

      

BMI, mean (SD)

29.8 (10.5)

27.3 (6.1)

28.1 (5.6)

33.0 (12.2)

0.067b

     
  1. The table corresponds to Fig. 6; Zhang + CTH is not included here because the trajectory model did not pass QC
  2. CTH, cell-type heterogeneity; SD, standard deviation; CSF, cerebrospinal fluid; BMI, body mass index
  3. aSmoking history: yes (current, social, and past smokers), no (never smoked)
  4. bOne-way ANOVA
  5. cChi-square or Fisher’s exact
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Epigenetics Communications

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