Fig. 6

Age acceleration trajectory plots for Horvath, Hannum, and Zhang epigenetic clocks. Note that the above plots portray inferred trajectory groups and are not directly comparable as the group membership changes between plots as shown in Table 2; n = 273 at up to five time points (N = 850 observations over 14 days post-aSAH condensed to 5 cross-sectional time points); times listed correspond to cross-sectional time points (time 1 [days 0 to 2], time 2 [days 3 to 5], time 3 [days 6 to 8], time 4 [days 9 to 11], time 5 [days 12 to 14]); 95% confidence intervals shown are for estimated trajectories and not observed trajectories. CSF, cerebrospinal fluid; CTH, cell-type heterogeneity; aSAH, aneurysmal subarachnoid hemorrhage. Note that the Levine trajectory models and Zhang CTH-adjusted model did not pass posterior quality control and are presented in the Supplementary Material