From: ANGPT1 methylation and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients
 | 450K | MethylSeq (N = 233) | ||
---|---|---|---|---|
Discovery (N = 68) | Discovery (N = 58) | Replication (N = 175) | p-valuea | |
Demographic | Â | Â | Â | Â |
 Age (years) | 53.7 ± 11.3 | 53.3 ± 11.2 | 52.5 ± 11.0 | 0.66 |
 Sex (female/male) | 48/20 (71%) | 39/19 (67%) | 129/46 (74%) | 0.40 |
 Race (white/black) | 57/9 (86%) | 50/8 (86%) | 154/17 (90%) | 0.47 |
 Smoke (yes/no) | 35/25 (58%) | 30/23 (57%) | 107/50 (68%) | 0.14 |
Clinical | Â | Â | Â | Â |
 Fisher (2/3/4) | 17 (26%)/ 34 (51%)/ 15 (23%) | 16 (28%)/ 32 (55%)/ 10 (17%) | 72 (41%)/ 79 (45%)/ 24 (14%) | 0.19 |
 DCI (yes/no) | 35/33 (51%) | 28/30 (48%) | 52/123 (30%) | 0.02 |
 Time of DCI (days post injury) | 6.5 ± 2.5 | 6.4 ± 2.3 | 5.8 ± 2.3 | 0.22 |
 GOS-3 (unfavorable/favorable) | 19/34 (36%) | 13/31 (30%) | 27/115 (19%) | 0.15 |
 GOS-12 (unfavorable/favorable) | 11/38 (22%) | 7/34 (17%) | 20/54 (27%) | 0.26 |
 MRS-3 (unfavorable/favorable) | 35/18 (66%) | 27/17 (61%) | 71/71 (50%) | 0.23 |
 MRS-12 (unfavorable/favorable) | 24/25 (49%) | 18/23 (44%) | 34/40 (46%) | 0.85 |
 Death-3 (dead/alive) | 5/48 (9%) | 3/41 (7%) | 17/125 (12%) | 0.42 |
 Death-12 (dead/alive) | 9/40 (18%) | 6/35 (15%) | 18/56 (24%) | 0.24 |