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Table 1 Characteristics of the study population

From: ANGPT1 methylation and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients

 

450K

MethylSeq (N = 233)

Discovery (N = 68)

Discovery (N = 58)

Replication (N = 175)

p-valuea

Demographic

    

 Age (years)

53.7 ± 11.3

53.3 ± 11.2

52.5 ± 11.0

0.66

 Sex (female/male)

48/20 (71%)

39/19 (67%)

129/46 (74%)

0.40

 Race (white/black)

57/9 (86%)

50/8 (86%)

154/17 (90%)

0.47

 Smoke (yes/no)

35/25 (58%)

30/23 (57%)

107/50 (68%)

0.14

Clinical

    

 Fisher (2/3/4)

17 (26%)/

34 (51%)/

15 (23%)

16 (28%)/

32 (55%)/

10 (17%)

72 (41%)/

79 (45%)/

24 (14%)

0.19

 DCI (yes/no)

35/33 (51%)

28/30 (48%)

52/123 (30%)

0.02

 Time of DCI (days post injury)

6.5 ± 2.5

6.4 ± 2.3

5.8 ± 2.3

0.22

 GOS-3 (unfavorable/favorable)

19/34 (36%)

13/31 (30%)

27/115 (19%)

0.15

 GOS-12 (unfavorable/favorable)

11/38 (22%)

7/34 (17%)

20/54 (27%)

0.26

 MRS-3 (unfavorable/favorable)

35/18 (66%)

27/17 (61%)

71/71 (50%)

0.23

 MRS-12 (unfavorable/favorable)

24/25 (49%)

18/23 (44%)

34/40 (46%)

0.85

 Death-3 (dead/alive)

5/48 (9%)

3/41 (7%)

17/125 (12%)

0.42

 Death-12 (dead/alive)

9/40 (18%)

6/35 (15%)

18/56 (24%)

0.24

  1. Variable values are presented as mean ± sd for continuous variables, category count followed by percentage of the first category for binary variables, and count (percentage) for multi-categorical variables. The discrepancy between count sum and sample size was a result of missingness in observations
  2. aCharacteristics of the MethylSeq discovery (N = 58) and replication sample (N = 175) were compared by t-test or Fisher’s exact test