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Table 1 Descriptive characteristics of study populations and analyzed samples (IOW and ELEMENT)

From: Assessing the effect of childbearing on blood DNA methylation through comparison of parous and nulliparous females

Discovery Cohort: IOW

Replication Cohort: ELEMENT

Characteristic

Study Population

( N  = 750)

Analyzed Samples

( n  = 89)

Test Stat ( p -value)

Characteristic

Study Population

( N  = 275)

Analyzed Samples

( n  = 54)

Test Stat ( p -value)

Age at T1: Mean (SD)

18 (0)

18 (0)

-

Age at T1: Mean (SD)

14.5 (2.2)

16.2 (1.3)

5.61 (< .0001)

Age at T2: Mean (SD)

26 (0)

26 (0)

-

Age at T2: Mean (SD)

16.4 (2.2)

19.2 (1.3)

-9.00 (< .0001)

BMI change (T1 to T2): Mean (SD)

1.58 (16.34)

2.47 (3.49)

0.78 (.4350)

BMI change (T1 to T2): Mean (SD)

1.40 (1.68)

1.15 (3.81)

1.22 (0.2250)

Smoking Cluster at T1: N (%)

  

4.62 (.2020)

Smoking Cluster at T1: N (%)

  

20.75 (.0001)

1 – non active and non-passive smokers at T1

185 (32.92%)

21 (23.60%)

1 – non active and non-passive smokers at T1

195 (71.69%)

41 (85.42%)

2 – passive and non-active smokers at T1

238 (42.35%)

48 (53.93%)

2 – passive and non-active smokers at T1

59 (21.45%)

0

3 – active and non-passive smokers at T1

7 (1.12%)

1 (1.12%)

3 – active and non-passive smokers at T1

7 (2.55%)

0

4 – active and passive smokers at T1

132 (21.35%)

19 (21.35%)

4 – active and passive smokers at T1

11 (4.04%)

7 (14.58%)

SES Status at T1: N (%)

  

4.25 (.1194)

SES Status at T1: N (%)

  

6.06 (.1085)

1 – high income, median housing, low education

161 (29.70%)

30 (34.88%)

1 – AMAI Score A/B

14 (5.09%)

0 (0.00%)

2 – median income, high housing, high education

215 (39.67%)

39 (45.35%)

2 – AMAI Score C

126 (45.82%)

33 (61.11%)

3 – low income, low housing, median education

166 (30.63%)

17 (19.77%)

3 – AMAI Score D

102 (37.09%)

15 (27.78%)

    

4 – AMAI Score E/F

33 (12.00%)

6 (11.11%)